Clayton Kershaw vs. Tim Lincecum -- Opening day at Dodger Stadium, against the Giants and with the Giants coming off a World Series title, this game has enough going for it to start with, add in two of the best young pitchers in the game and it's an embarrassment of riches. (Thursday, 8 p.m. EST at Dodger Stadium, Los Angeles)
CC Sabathia vs. Justin Verlander -- There'll be no shortage of heat at Yankee Stadium tomorrow. Sabathia is starting his third straight opening day for the Yankees, while Verlander's strong spring give hope to avoiding another rough April. Not only do you have two of the best pitchers in the game going head-to-head, they're both facing formidable lineups. (Thursday, 1:05 p.m. EST at Yankee Stadium, New York)
Felix Hernandez vs. Trevor Cahill -- Hernandez won his first Cy Young Award last season, while Cahill is at the top of what is probably the American League's best rotation. We all know Hernandez's resume, but Cahill had an impressive 2010 as well, going 18-8 with a 2.97 ERA. (Friday, 10:05 p.m. EST at Oakland Coliseum in Oakland, Calif.)
Ryan Dempster vs. Kevin Correia -- Correia goes from being another guy in a very good rotation in San Diego a year ago to the top of the Pirates' rotation. Dempster has started two opening days before, both in Florida, but is hardly a marquee name for one of the game's marquee franchises. (Friday, 2:20 p.m. EST at Wrigley Field in Chicago)
Derek Lowe vs. Livan Hernandez -- Lowe's starting his third straight opening day for the Braves and Hernandez is making his fourth overall opening day start for the Nationals/Expos, but first since 2006. Both have had good careers, but there's little sizzle to this matchup. (Thursday, 1:05 p.m. EST at Nationals Park, Washington, D.C.)
Tim Stauffer vs. Chris Carpenter -- With all due respect to the 2005 Cy Young Award winner, this game is as much about who isn't pitching as who will toe the rubber. The expectation was that it would be Mat Latos against Adam Wainwright, this just doesn't have the same juice. (Thursday, 4:15 p.m. EST at Busch Stadium, St. Louis)For more baseball news, rumors and analysis, follow @cbssportsmlb on Twitter or subscribe to the RSS feed.